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Few things can derail your household like a sudden flea infestation. Whether you have a dog or a cat, fleas go beyond making your pet miserable. They can take up residence in your bedding, furniture or carpeting and lay eggs. Luckily, there are plenty of treatments that can give your cat some relief. We spoke with veterinarians to find out what they recommend as the best flea treatments for cats.
What to consider when selecting flea treatments for cats
Cat and dog flea treatments have a similar goal, but they use different chemicals to do the job. It’s important, then, to choose a product specifically designed for cats if your feline has fleas. Here are the factors to consider when you’re looking for a flea treatment for your cat:
Protection provided
Flea medicine kills fleas, right? Yes, but that isn’t the only purpose it serves. Many flea medicines also protect against a variety of problematic pests, including:
- Ticks.
- Lice.
- Heartworms.
- Roundworms.
- Tapeworms.
When you’re looking for the best flea treatments for cats, consider the comprehensiveness of the protection. Some flea treatments only kill adult fleas, leaving the larvae and eggs behind. These elimination treatments often don’t provide protection, so you’ll still face the risk of a future infestation.
Other household pets
When you have more than one pet, you have to make sure they’re all protected to prevent a full infestation. “Most flea products protect the animal and the house from infestation,” says Dr. Joanna Woodnutt, MRCVS, a veterinarian at Petlearnia. “If the pet acquires a flea — or even several — while outside, the flea dies as soon as they feed from the pet before they can lay eggs. However, this only works if all pets in the house are protected, as otherwise, they might feed from the unprotected pet, lay eggs and start a flea infestation.”
Prevention vs. elimination
Does your cat already have fleas? If so, you’ll need to first eliminate them. But products that help you clear up an infestation aren’t always the best treatments to prevent pests on an ongoing basis. “If your cat is suffering from flea infestations, your veterinarian may prescribe an oral medication like lufenuron or nitenpyram,” says Dr. Bethany Hsia, DVM and co-founder of CodaPet.
Once you’ve cleared the infestation, you can choose a flea treatment to prevent future issues. These products are designed to be administered on a schedule to ensure your cat is protected around the clock.
Prescription vs. over-the-counter
There’s no shortage of over-the-counter products to prevent and treat fleas in cats. But prescription flea medications can be more effective than over-the-counter options, particularly if they’re better-suited to your pet. You don’t need a prescription to get a vet recommendation, though. Your vet knows your pet’s medical history and can advise you on the best product for your pet’s needs.
That said, there are downsides to choosing a prescription option. These treatments tend to be more expensive, for one. You’ll also have to either purchase the medication from your vet or wait for vet confirmation before a retailer can complete your purchase.
Application method
Flea medications come in various formats, each with pros and cons. You’ll need to consider whether your cat will do better with a pill, topical solution or collar. “Oral flea and tick medications are preferred by some pet parents for their simplicity and cleanliness,” says Dr. Nick Horniman, MRCVS, veterinary surgeon and founder of myPetsVet. “These treatments eliminate the mess associated with topical applications and the risk of the medication rubbing off onto furniture or human skin.”
Frequency of application
Once you start your cat on a flea treatment, you’ll need to stay consistent. This typically means applying once a month, as each dose lasts 30 days. Some options, such as flea collars, can last up to three months, which may be a better choice for you and your cat if administering the medicine once a month proves challenging.
Our top picks for the best flea treatments for cats
Best topical flea treatments for cats: Senergy Topical Solution for Cats
Senergy Topical Solution for Cats
Available in three size ranges by weight, this prescription topical solution protects against heartworms, fleas, ear mites, hookworms and roundworms. You’ll need to apply once every month for ongoing protection. Reported side effects include digestive and skin issues.
Specifications
- Active ingredient(s): Selamectin.
- Doses: 2.7 milligrams of selamectin per pound of body weight.
- Quantity: Three doses.
- Application method: Topical.
- Prescription required: Yes.
- Price on publish: $47.90.
What we like:
- Easy to apply.
- Holds up with shampoo.
- Covers all three stages of flea infestations.
What we don't Like:
- Requires prescription.
- No tick prevention.
- Some cat hair loss cases reported.
The AP Buyline takeaway
If you’re looking for both heartworm and flea protection in one product, this is a great option, but you won’t get protection against ticks or lice.
Get here: Senergy Topical Solution for Cats
Best flea treatment for cats for a budget: Advantage II Flea Spot Treatment for Cats
Advantage II Flea Spot Treatment for Cats
The per-dose price of this flea treatment is more affordable than many options, making it a great long-term solution for pet owners on a budget. You’ll apply the treatment every 30 days for ongoing protection against fleas. The downside of this option? No protection against other pests, including ticks and lice.
Specifications
- Active ingredient(s): Imidacloprid and pyriproxyfen.
- Doses: One treatment every 30 days.
- Quantity: Six applications.
- Application method: Topical.
- Prescription required: No.
- Price on publish: Starts at $32.48.
What we like:
- Affordable.
- Waterproof.
- Fragrance-free.
What we don't Like:
- No lice or tick protection.
- Protection can wane early.
- May not be safe for breeding or pregnant cats.
The AP Buyline takeaway
If you’re looking for an easy-to-use, affordable flea prevention for long-term use, Advantage II has you covered.
Best flea treatment for cats for infestations: Capstar (Nitenpyram) Fast-Acting Oral Flea Treatment for Cats
Capstar (Nitenpyram) Fast-Acting Oral Flea Treatment for Cats
When an infestation has already occurred, Capstar’s flea protection is a great option. The product takes effect within 30 minutes, killing 90% of fleas within six hours.Side effectsare rare but include increased or decreased energy, itching, vomiting, diarrhea and lack of appetite.
Specifications
- Active ingredient(s): Nitenpyram.
- Doses: One tablet per dose.
- Quantity: Six tablets.
- Application method: Oral.
- Prescription required: No.
- Price on publish: $34.45
What we like:
- Fast-acting.
- Affordable.
- No ongoing use required.
What we don't Like:
- Not a preventive.
- Only kills adult fleas.
- Not effective in all cases.
The AP Buyline takeaway
This tablet works well for infestations, but you’ll also need to use a preventive after 24 hours have passed.
Get here: Capstar (Nitenpyram) Fast-Acting Oral Flea Treatment for Cats
Best fast-acting flea treatments for cats: Credelio Chewable Tablets for Cats
Credelio Chewable Tablets for Cats
Credelio is great for existing infestations, killing fleas within six hours of treatment. Like Capstar, Credelio is designed to tackle existing adult fleas, so you’ll need a preventive once the infestation is cleared up. Although side effects are rare, the FDAhas issued a warningabout possible neurological adverse reactions, including muscle tremors, ataxia and seizures in some dogs and cats.
Specifications
- Active ingredient(s): Lotilaner.
- Doses: One tablet per dose.
- Quantity: Six tablets.
- Application method: Oral.
- Prescription required: Yes.
- Price on publish: $110.62.
What we like:
- Fast-acting.
- Kills fleas and ticks.
- Chewable.
What we don't Like:
- Not a preventive.
- No heartworm prevention.
- Not tested in breeding or pregnant cats.
The AP Buyline takeaway
For treatment that can eliminate an infestation within six hours, Credelio can tackle the job, but its preventive power is limited.
Get here: Credelio Chewable Tablets for Cats
Best collar flea treatments for cats: Sentry PurrScriptions Plus Flea and Tick Shampoo
Sentry PurrScriptions Plus Flea and Tick Shampoo
This flea collar gradually releases protection into your cat’s skin, killing fleas on contact to avoid an infestation. Each collar lasts up to eight months and has a water-resistant formula that allows you to bathe your cat without the collar losing effectiveness.Reported side effectsinclude skin irritation, dizziness and loss of appetite.
Specifications
- Active ingredient(s): Imidacloprid, flumethrin.
- Doses: One collar every eight months.
- Quantity: One collar.
- Application method: Collar.
- Prescription required: No.
- Price on publish: $59.98.
What we like:
- Works for fleas and ticks.
- Long-lasting protection.
- Water-resistant.
- More affordable than monthly treatments.
What we don't Like:
- Requires cat to wear a collar.
- No mosquito protection.
- Some potential side effects.
The AP Buyline takeaway
If you prefer a collar to a pill or topical treatment, Seresto’s flea and tick collar is an affordable option.
Best flea treatment shampoo for cats: Sentry PurrScriptions Plus Flea and Tick Shampoo
Sentry PurrScriptions Plus Flea and Tick Shampoo
This shampoo offers multiphase elimination and prevention. It kills fleas and prevents the development of eggs and larvae for ongoing protection. Built-in conditioners and a pleasant scent make it a palatable alternative to topical treatments.
Specifications
- Active ingredient(s): Pyrethrins, n-octyl bicycloheptene dicarboximide and pyriproxyfen.
- Doses: As needed, plus once every 30 days for ongoing protection
- Quantity: 12-ounce bottle.
- Application method: Shampoo.
- Prescription required: No.
- Price on publish: $9.99.
What we like:
- Conditions and cleanses.
- Pleasant scent.
- Repels mosquitoes.
What we don't Like:
- No unscented option.
- May not be as effective as alternatives.
- Can irritate if it gets in eyes or mouth.
The AP Buyline takeaway
This flea shampoo can be great for managing an existing infestation, but for ongoing protection, it’s not the most powerful option.
Best flea treatments for kittens: Frontline Plus Cat Flea & Tick Treatment
Frontline Plus Cat Flea & Tick Treatment
Frontline is marked safe for kittens weighing at least 1.5 pounds and ages 8 weeks and older. It kills fleas, ticks and lice, and each application lasts 30 days. Side effects include itching and other signs of discomfort, particularly at the site of application.
Specifications
- Active ingredient(s): Fipronil and (S)-methoprene.
- Doses: One application every 30 days.
- Quantity: Three applications.
- Application method: Topical.
- Prescription required: No.
- Price on publish: $39.98.
What we like:
- Kills ticks and lice.
- Waterproof.
- Safe for breeding and lactating cats.
What we don't Like:
- Doesn’t repel fleas, ticks or mosquitos.
- Can take 12 hours to start working.
- No heartworm protection.
The AP Buyline takeaway
For kittens and pregnant or lactating cats, this option is one of the best, although it’s important to consult your veterinarian before administering any treatments.
Get here: Frontline Plus Cat Flea & Tick Treatment
Best flea treatment spray for cats: Vet's Best Flea and Tick Home Spray for Cats
Vet's Best Flea and Tick Home Spray for Cats
Once a flea infestation sets in, it can spread around your entire home. Vet’s Best lets you spray not just your pets but other items in your home where fleas may linger, for more thorough pest removal. The best thing about this spray is that you can reapply it every two to four hours as needed.
Specifications
- Active ingredient(s): Peppermint oil, eugenol and sodium lauryl sulfate.
- Doses: Light coating on pet’s fur and surrounding surfaces.
- Quantity: 32 fluid ounces.
- Application method: Spray.
- Prescription required: No.
- Price on publish: $15.39.
What we like:
- Plant-based ingredients.
- Kills fleas and ticks.
- Helps remove fleas from household items.
What we don't Like:
- No prevention.
- Strong smell.
- Sprayer can malfunction.
The AP Buyline takeaway
This spray is great for eliminating fleas on pets and in households, but it’s not the best long-term preventive solution.
Best flea and tick treatment for cats: NexGard COMBO Topical for Cats
NexGard COMBO Topical for Cats
You’ll get ongoing protection from a variety of parasites with one monthly application of this treatment. NexGard protects against fleas, ticks, tapeworms, hookworms, roundworms and heartworms. Although the FDA has approved it as safe, the agency has highlighted somereported adverse reactionsto be aware of, including muscle tremors, ataxia and seizures.
Specifications
- Active ingredient(s): Esafoxolaner, eprinomectin and praziquantel.
- Doses: One application every 30 days.
- Quantity: One to six applications.
- Application method: Topical.
- Prescription required: Yes.
- Price on publish: Starts at $25.19.
What we like:
- Kills tapeworms.
- Fast-acting.
- Chewable.
What we don't Like:
- Doesn’t repel fleas, ticks or mosquitos.
- Not approved for breeding or pregnant cats.
- Can cause adverse reactions.
The AP Buyline takeaway
Pill-based preventives have their pros and cons, but this chewable provides plenty of advantages, including its comprehensive protection.
Get here: NexGard COMBO Topical for Cats
Best long-lasting flea treatments for cats: Bravecto Topical Solution for Cats
Bravecto Topical Solution for Cats
One application of Bravecto Topical Solution lasts for 12 weeks, making it a workable option for those who don’t want to keep track of administering treatment every month. It protects against fleas and ticks, killing adult fleas on contact. The list of potential side effects is fairly long, though, and some cats are allergic to the ingredients.
Specifications
- Active ingredient(s): Fluralaner.
- Doses: One application every 12 weeks.
- Quantity: One tube.
- Application method: Topical.
- Prescription required: Yes.
- Price on publish: $68.99.
What we like:
- Long-lasting protection.
- Prevents fleas and ticks.
- Immediately kills adult fleas.
What we don't Like:
- Pricey.
- Not for use on cats aged 6 months or younger.
- May cause reactions in some pets.
The AP Buyline takeaway
Bravecto’s long-lasting formula makes it a great solution for someone who doesn’t want to apply a treatment every month.
Get here: Bravecto Topical Solution for Cats
How we selected the best flea treatments for cats
With so many options, it can be tough to narrow the best flea treatments down to only one. For that reason, I compiled a broad range of choices, from more affordable options to more expensive prescriptions. I also included a balance of preventive products and flea treatments designed to kill off fleas during an infestation. Lastly, I included a range of applications to fit all preferences.
Types of flea treatments for cats
When selecting the best treatment for you and your cat, you’ll want to consider which chemicals you’re willing to use in your household, whether you have an active infestation or are looking to prevent one and your cat's preferences.
- Oral: Often provided in chewable form, this option is best for pets who take oral medications well.
- Topical: Typically offered in a dosed applicator, this treatment can be tricky to apply but eliminates the need to try to get a pet to ingest medication.
- Shampoos: Flea shampoos are typically used on existing infestations, although some do provide protection as well as elimination.
- Collars: This set-it-and-forget-it option is long-lasting, but you’ll need to leave the collar on your cat around the clock.
- Sprays: Like shampoos, this option is typically recommended to treat an existing infestation.
How do flea treatments work?
Both cat and dog flea treatments work by releasing chemicals through the pet’s sebaceous glands, which are located in the skin. The glands emit those chemicals, killing and/or repelling fleas and, in some cases, other pests. This absorption process can take a while, though.
“Flea treatments take different amounts of time to work depending on the product,” advises Woodnutt. “The shortest would be some of the oral products, which work within 15 minutes. Most spot-ons take 12 to 24 hours to be absorbed and redistributed so that they work.”
How to prevent flea infestations
Getting control of a flea infestation can be challenging, to say the least. It’s far better to prevent one from happening in the first place. “There are several measures that a cat owner can take to minimize the risk of flea infestations,” Hsia says. “First of all, inspect your cat regularly for signs of fleas, such as excessive scratching or biting at the skin. Second, keep your living environment clean by regularly vacuuming floors and washing your cat’s bedding and cat toys. Third, keep your cat’s coat clean and groom them regularly. Moreover, avoid crowded areas, like pet day cares, where potentially infested pets may be present. Lastly, use preventive products consistently as recommended by your veterinarian.”
Frequently asked questions (FAQs)
What is the most effective cat flea treatment?
Effectiveness depends on the cat and the level of exposure to fleas. It’s important to consult your vet before starting any treatment to determine the best option for your pet. “The most effective way to treat fleas on cats is to use veterinarian-recommended topical treatments, oral medications or flea collars,” says Horniman. “These products are designed to kill fleas at various life stages and offer protection ranging from one month to several months.”
Which flea medicines do vets recommend?
Recommendations can vary from one vet to another. Hsia likes topical treatments that contain ingredients like pyrethrin and pyrethroid, which can be found in products like Advantix and Seresto.
“For cats, I recommend using topical preventive products containing ingredients like pyrethrin and pyrethroid, that work by inhibiting the central nervous system of fleas upon contact and prevent them from biting and laying eggs on your cat’s body,” she says. “I recommend trying topical treatments first as they are easy to apply and offer coverage against fleas and other parasites like ticks and ear mites.”
What is the best thing to keep fleas off cats?
Woodnutt cautions against products made with fipronil, which is found in brands like Frontline. She points out that many people find fipronil less effective than it once was and that it poses a threat to the ecosystem.
“For this reason, I tend to advise opting for an oral product or a topical product without fipronil,” she says. “The most important thing is to apply them properly, read all of the instructions and reapply them as instructed. Leaving a gap of just a day can allow an infestation to start.”
AP Buyline’s content is created independently of The Associated Press newsroom. Our evaluations and opinions are not influenced by our advertising relationships, but we might earn commissions from our partners’ links in this content. Learn more about our policies and terms here.
